경력 : Neuracle Science, 전임상본부 총괄 (2022.1 ~2022.12) GENUV, 수석연구원 (2020.8 ~ 2022.1) Beckman Research Institute of City of Hope, Staff scientist (2011.2 ~ 2020.2) Torrey pines Institute of Molecular Studie, 방문연구사( 2004.6 ~ 2006.5) 농림축산검역본부, 수의연구사 (1998.8 ~ 2013.5)
논문: - Andrikakou P, Reebye V, Vasconcelos D, Yoon S, Voutila J, George AJT, Swiderski P, Habib R, Catley M, Blakey D, Habib NA, Rossi JJ, Huang KW. Enhancing SIRT1 Gene Expression Using Small Activating RNAs: A Novel Approach for Reversing Metabolic Syndrome. Nucleic Acid Ther. 2022 Dec;32(6):486-496. doi: 10.1089/nat.2021.0115. Epub 2022 Jul 27. -Yoon S, Li H, Quintanar L, Armstrong B, Rossi JJ. Uncovering Differently Expressed Markers and Heterogeneity on Human Pancreatic Cancer.Transl Oncol. 2020 Mar;13(3):100749 -Yoon S, Huang KW, Andrikakou P, Vasconcelos D, Swiderski P, Reebye V, Sodergren M, Habib N, Rossi JJ. Targeted Delivery of C/EBPα-saRNA by RNA Aptamers Shows Anti-tumor Effects in a Mouse Model of Advanced PDAC. Mol Ther Nucleic Acids. 2019 Aug 22;18:142-154. -Yoon S, Wu X, Armstrong B, Habib N, Rossi JJ. An RNA Aptamer Targeting the Receptor Tyrosine Kinase PDGFRα Induces Anti-tumor Effects through STAT3 and p53 in Glioblastoma. Mol Ther Nucleic Acids. 2018 Dec 1;14:131-141. -Yoon S, Rossi JJ. Aptamers: Uptake mechanisms and intracellular applications. Adv Drug Deliv Rev. 2018 Jul 6. -Yoon S, Armstrong B, Habib N, Rossi JJ. Blind SELEX Approach Identifies RNA Aptamers That Regulate EMT and Inhibit Metastasis, Mol Cancer Res. 2017 Apr 10 (selected Highlights, July 2017, 15(7)) -Yoon S, Huang KW, Reebye V, Spalding D, Przytycka TM, Wang Y, Swiderski P, Li L, Armstrong B, Reccia I, Zacharoulis D, Dimas K, Kusano T, Shively J, Habib N and Rossi J, Aptamer drug conjugates (ApDCs) of active metabolites of nucleoside analogues and cytotoxic agents inhibit pancreatic tumor cell growth. Molecular Therapy - Nucleic Acids. 2017 60:80-88. -Yoon S, Huang KW, Reebye V, Mintz P, Tien YW, Lai SH, Sætrom P, Reccia I, Swiderski P, Armstrong B, Jozwiak A, Spalding D, Jiao L, Habib N, and Rossi J. Targeted Delivery of C/EBPα -saRNA by Pancreatic Ductal Adenocarcinoma (PDAC)-specific RNA aptamers Inhibits Tumor Growth in vivo. Molecular therapy. 2016 24:1106-1116. -Lee G, Han D, Song JY, Kim JH, Yoon S. Proteomic analysis of swine hepatitis E virus (sHEV)-infected livers reveals upregulation of apolipoprotein and downregulation of ferritin heavy chain. FEMS Immunol Med Microbiol. 2011 61(3):359-63. -Yoon S, Lee G, Han D, Song JY, Kang KS, Lee YS, Neutralization of infectivity of porcine circovirus type 2 (PCV2) by capsid-binding 2′F-RNA aptamers. Antiviral Res. 2010. 88:19-24. -Lee G, Han D, Song JY, Lee YS, Kang KS, Yoon S. Genomic expression profiling in lymph nodes with lymphoid depletion from porcine circovirus 2 (PCV2)-infected pigs. JGV. 2010. 91:2585-2591. -Lee, LN, Dias, P, Han, D, Yoon S, Parham, D, Zakharov, V, Sarawar, SR. A Mouse Model of Lethal Synergism between Influenza Virus and Haemophilus influenzae. Am J Pathol. 2010. 176 :536-9. -Dias P, Giannoni F, Lee LN, Han D, Yoon S, Yagita H, Azuma M and Sarawar SR, CD4 T cell help programs a change in CD8 T cell function enabling effective long-term control of murine gammaherpesvirus-68. Role of PD-1-PD-L1 interactions. JVI. 2010.84:8241-9
저서: Treatment of Pancreatic cancer by Aptamer Conjugated C/EBP-saRNA, RNA activation (pp173 ~ 188), part of the Advances in Experimental Medicine and Biology book series
활동: 대한수의사회
경력
면허 : 수의사
경력 : Neuracle Science, 전임상본부 총괄 (2022.1 ~2022.12)
GENUV, 수석연구원 (2020.8 ~ 2022.1)
Beckman Research Institute of City of Hope, Staff scientist (2011.2 ~ 2020.2)
연구 및 박사 논문 - Antimicrobial, Antioxidative, Elastase and Tyrosinase Inhibitory Effect of Supercritical and Hydrothermal Asparagopsis armata Extract - Antimicrobial Effect of Supercritical Robinia pseudo-acacia Leaf Extracts and Its Transdermal Delivery System with Cell Penetrating Peptide - 미세먼지 자극으로부터 지모추출물,베타글루칸,폴리감마글루탐산 혼합물의 안티폴루션 효능 평가 - 미세먼지로 자극된 대식세포에서 지모추출물, 베타글루칸, 폴리감마글루탐산 혼합물의 항염증 효과와 안티폴루션 화장품으로 응용